Vesicles, not living cells
Exosomes are a type of extracellular vesicle. They do not divide or turn into new tissue.
PURE BONE MARROW EXOSOMES
PBME Topical™
A closer look at
cellular communication.
Bone marrow MSC-derived extracellular vesicles in a 5 mL vial for topical cosmetic use. Explore composition, processing, and the research behind the field.
R812 / PRODUCT PORTFOLIO02
5 mLSingle-use vial
>50 billionListed exosomes/vial*
TopicalCosmetic use only
*Product specifications; current labeling and lot documentation take precedence.
PRODUCT AT A GLANCE
Understand what
is inside.
PBME Topical contains extracellular vesicles and regulatory proteins. Extracellular vesicles are released by cells; they are not cells themselves.
The product information describes proprietary isolation and purification, sterile filtration, and USP <71> sterility testing.
5 mLSingle-use vial
TopicalIntended application only
FrozenCold storage required
COMPOSITION / A CLOSER LOOK
Small vesicles.
A complex molecular profile.
1,000+regulatory proteins described
in product information
in product information
Selected proteins listed in PBME Topical’s composition information. The biological roles below describe general protein biology; their presence does not establish a clinical effect of this product.
| Protein | Full name | Biological context |
|---|---|---|
| VEGFR | VEGF receptor | VEGF signal reception |
| VEGF | Vascular endothelial growth factor | Vascular development & cell migration |
| Ang1 | Angiopoietin-1 | Vascular signaling |
| TIMP-1 | Tissue inhibitor of metalloproteinases-1 | Extracellular matrix regulation |
| TIMP-2 | Tissue inhibitor of metalloproteinases-2 | Extracellular matrix regulation |
| IL-1β | Interleukin-1 beta | Inflammatory signaling |
| PDGF-AA | Platelet-derived growth factor AA | Cell growth & migration |
| TGF-β3 | Transforming growth factor beta 3 | Cell differentiation & immune signaling |
| bFGF | Basic fibroblast growth factor | Cell growth signaling |
| HGF | Hepatocyte growth factor | Cell growth & tissue-response signaling |
10 proteins shown
Request current product characterization and lot documentation from R812.
CONCEPTUAL VISUALIZATION / NOT TO SCALETHE SCIENCE OF EXTRACELLULAR VESICLES
A message.
At a different scale.
Extracellular vesicles are membrane-bound particles released by cells. Their cargo can include proteins, lipids, and RNA, and researchers study how they participate in communication between cells.
Source and process matter
Cell source, isolation methods, and characterization affect the material being studied. Results from one preparation cannot simply be transferred to another.
EXOSOME SCIENCE / SELECTED READING
Go deeper.
Read the original work.
Selected for their relevance to study quality, bone marrow MSCs, and skin biology.
CONSENSUS GUIDANCE
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
A field consensus on EV separation, characterization, study design, and transparent reporting. A foundation for assessing the quality of exosome research.
2024Read PDF
PRECLINICAL STUDY
Human bone marrow mesenchymal stem cell-derived exosomes stimulate cutaneous wound healing mediates through TGF-β/Smad signaling pathway
Examines human bone marrow MSC-derived exosomes in cell cultures and a rat skin-wound model. This is mechanistic research, not a PBME Topical clinical trial.
2020Read publication
IN VITRO STUDY
Human Mesenchymal Stromal Cell-Derived Exosomes Promote In Vitro Wound Healing by Modulating the Biological Properties of Skin Keratinocytes and Fibroblasts and Stimulating Angiogenesis
Studies bone marrow MSC-derived exosomes in laboratory skin-cell and angiogenesis models. Findings provide biological context; they do not establish product efficacy in people.
2021Read publication
These are independent publications about extracellular vesicles. They do not test PBME Topical. Clinical claims require evidence for the exact product, route, and intended use.
HANDLING WITH CLARITY
The details
matter.
Confirm current labeling, storage conditions, and application instructions before use. For product-specific questions, contact the R812 team.
Ask a product questionHow is PBME Topical applied?+
PBME Topical is for topical applications only. Follow the current manufacturer instructions for thawing, handling, and application. Do not infer injectable uses from publications about other extracellular vesicle products.
How is the product processed?+
The existing product information describes proprietary isolation and purification from human bone marrow MSCs, processing in a cGMP facility, sterile filtration, and USP <71> sterility testing.
What are the storage requirements?+
PBME Topical is supplied frozen. Confirm the storage temperature, expiry date, thawing instructions, and post-thaw use window on the current lot label before scheduling use. Published storage guidance differs between sources; request the current written instructions from R812. Do not store in liquid nitrogen.
How should I interpret the research library?+
The library contains general extracellular vesicle research, including studies of other products, animal models, and investigational routes. These publications do not establish PBME Topical indications, safety, or efficacy for those uses.
Where can I place an order?+
Use the customer portal to sign in. If your clinic needs access, use the portal’s request-account flow.
LET’S MOVE FORWARD
The next step.
Taken together.
Explore products for your practice, request clinic access, or speak with our team about your needs.