Three-layer structure
Amnion, intermediate layer, and chorion remain combined.
PLACENTAL TISSUE ALLOGRAFT
AmnioWrap2®
Native layers.
Purposeful protection.
An amnion/chorion allograft that preserves the intermediate layer. Explore the architecture, biological components, and clinical context behind this protective covering.
R812 / PRODUCT PORTFOLIO01
3Native tissue layers
AmbientStorage
4 yearsListed shelf life*
*Product specifications; current labeling and lot documentation take precedence.
AMNIOWRAP2 / PRODUCT CHARACTERISTICS
Native architecture.
Practical clinical handling.
Retained matrix
Naturally occurring extracellular matrix components and regulatory proteins.
Protective covering
Intended for homologous use as a protective covering.
Ambient storage
No frozen storage requirement. Follow current product labeling.
Terminally sterilized
Aseptic processing with e-beam terminal sterilization.
Listed four-year shelf life
Confirm the expiration date printed on each individual package.
NATURAL ARCHITECTURE
Three layers.
One protective covering.
AmnioWrap2 preserves the combined amnion, intermediate layer, and chorion, including the extracellular matrix and naturally occurring regulatory proteins found in placental tissue.
The BioRetain® process is designed to preserve native tissue components. Explore each layer below.
The amniotic membrane contributes native extracellular matrix components to the combined tissue covering.
CONCEPTUAL TISSUE ARCHITECTUREINSIDE THE ALLOGRAFT
The structure
is part of the story.
Placental membranes contain an extracellular matrix: a structural network that includes collagen and other tissue components. AmnioWrap2 retains the intermediate layer between the amnion and chorion.
Understand tissue allografts
H&E stain: nuclei appear purple; extracellular matrix appears pink. Original R812 product imagery.
PRACTICAL PRODUCT DETAILS
Designed for
clinical handling.
PROCESSING
Aseptic processing
Terminally sterilized using e-beam irradiation.
STORAGE
Ambient temperature
Refer to the current label and instructions for use for storage conditions.
SHELF LIFE
4 years
Use the expiration date on the individual product label.
Product specifications reflect the existing R812 product information. Always follow the current manufacturer instructions for use.
WOUND-TO-GRAFT PLANNING
Find a dimensional fit.
Compare rectangular dimensions with the listed graft range.
DIMENSIONAL MATCH
Your fit starts here.
Enter both measurements to find the smallest listed sheet that covers the dimensions, allowing rotation.
View the complete listed size range +
CLINICAL CONTEXT
Look beyond
the headline.
The library includes a retrospective comparison of retention-processed amnion/chorion membranes and standard of care in diabetic foot ulcers, alongside wound-care case studies.
Review the full methods, study limitations, and patient population when interpreting results.
Explore AmnioWrap2 resourcesWhat is AmnioWrap2 intended for?+
Homologous use as a protective covering. Refer to the current product instructions for use for complete indications and handling.
What is retained in the allograft?+
Amnion, the intermediate layer, and chorion. R812’s product information describes retained extracellular matrix components, cytokines, and endogenous growth factors.
How do I order?+
Existing customers can sign in to the R812 customer portal. Clinics that need access can use the account request flow. Distribution enquiries should be directed to the R812 team.
TISSUE ALLOGRAFTS / COVERAGE & ACCESS
Coverage starts
with the right questions.
Medicare and some commercial plans may cover qualifying tissue-based wound products when their policy criteria are met. Coverage is specific to the product, indication, patient, and care setting.
Explore coverage considerationsConfirm the policy
Check the patient’s plan, the applicable Medicare contractor, and the exact product.
Document the clinical need
Review wound history, prior standard care, measurements, and the treatment plan.
Verify before treatment
Confirm authorization, coding, benefit limits, and patient responsibility with the payer.
Coverage is not guaranteed for AmnioWrap2 or any individual claim. This tissue-allograft information does not apply to PBME Topical. Sources: CMS coverage policy · Commercial payer example.
LET’S MOVE FORWARD
The next step.
Taken together.
Explore products for your practice, request clinic access, or speak with our team about your needs.